Superoxide Reductases (SOR) are a class of non-heme iron enzymes which catalyse the monovalent reduction of superoxide to hydrogen peroxide and are involved in the oxidative stress defences of anaerobic and microaerophilic organisms. The active site of SOR is highly conserved and consists of a pentacoordinated Fe2+ centre with four equatorial histidines and one axial cysteine in a square pyramidal geometry (centre II, Fe(His)4(Cys)).





SORGOdb is an exhaustive database of SOR that proposes a new classification based on domain architecture. Using anchor-based inspection on six frame-translated genomes, we detect new SOR loci in prokaryotic genomes and surprisingly, in some eukaryotes [diatoma and fungi] which were believed not to contain SOR. Our interface using various criteria, such as phylogeny, locus tag name and organism name, facilitates analysis of SOR architecture variations, clarification of the phylogeny of SOR and establishing correlations between type of SOR and organism phylogeny/phenotype. SORGO also offers sequence similarity search functions using BlastP with the SORGOdb dataset.

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